Publications

2026

Metabolic Dysregulation in Laminopathies: Implications for Heart Failure and Cardiac Health.

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Association of poor vitamin K status with inflammation and gut microbiota in hemodialysis patients: A cross-sectional study.

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Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure.

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Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity.

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Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research.

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Rethinking Aortic Risk: The Potential Impact of Novel, Adjusted, and Combined Aortic Measures in the Prediction of Aortic Dissection.

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2025

Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.

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Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?

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Jaw-specific differential kinase activity profiles in human periodontal ligament stem cells under mechanical compression.

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The clinical relevance of the decelerating effect of angiotensin receptor blockers on aortic growth in Marfan patients; a Bayesian perspective.

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Hypotaurine Reduces Glucose-Mediated Vascular Calcification.

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Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants.

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Integrative analysis of 115 transcriptomic studies decodes the molecular landscape of neurodevelopmental disorders.

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miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues.

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Vasoconstriction-inhibiting factor: an endogenous inhibitor of vascular calcification as a calcimimetic of calcium-sensing receptor.

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Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.

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Resveratrol modulates phosphorylation of ERK and AKT in murine cementoblasts during in vitro orthodontic compression.

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Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling.

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A novel missense variant in TNFAIP3 associated with autoimmunity reveals the contribution of STAT1/mTOR pathways.

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A randomized prospective crossover study on the effects of medium cut‑off membranes on FGF-23 and inflammatory mediators in patients receiving regular haemodialysis.

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Human Aortic Vasoreactivity in Response to Various Stimuli: A Review.

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Interpretation of intra-operative strain differences in ascending thoracic aortic repair patients.

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LeDucq-funded programme: from pathomechanisms to personalized therapy of cardio-laminopathy

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2024

Distribution and Maturity of Medial Collagen Fibers in Thoracoabdominal Post-Dissection Aortic Aneurysms: A Comparative Study of Marfan and Non-Marfan Patients.

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Gla-Rich Protein Is Associated with Vascular Calcification, Inflammation, and Mineral Markers in Peritoneal Dialysis Patients.

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Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics.

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Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension.

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Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids.

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Changes in the gut microbiota of pseudoxanthoma elasticum patients.

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Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections.

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A novel insight into neurological disorders through HDAC6 protein-protein interactions.

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Fundamental considerations for designing endothelialized in vitro models of thrombosis.

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Mediterranean Diet Favors Vitamin K Intake: A Descriptive Study in a Mediterranean Population.

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From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy.

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Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health.

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The role of vitamin K2 in cognitive impairment: linking vascular health to brain health.

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2023

Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort.

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Plasma Dephosphorylated-Uncarboxylated Matrix Gla-Protein in Systemic Sclerosis Patients: Biomarker Potential for Vascular Calcification and Inflammation.

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Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on Vascular Calcification in Hemodialysis Patients (Trevasc-HDK).

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The Maastricht Acquisition Platform for Studying Mechanisms of Cell-Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease.

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Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs.

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Common Histological Features Suggesting Enchondral Ossification Pathways in Calciphylaxis of Various Origins: A Study of Human Subcutaneous Tissue Biopsies.

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Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol.

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New Food Frequency Questionnaire to Estimate Vitamin K Intake in a Mediterranean Population.

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Development of a cyclic-inverso AHSG/Fetuin A-based peptide for inhibition of calcification in osteoarthritis.

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Vitamin K and Hallmarks of Ageing: Focus on Diet and Gut Microbiome.

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Microvesicle-Mediated Tissue Regeneration Mitigates the Effects of Cellular Ageing.

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Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification.

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Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial.

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Real world evidence: Perspectives from a European Society of Cardiology Cardiovascular Round Table with contribution from the European Medicines Agency.

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The Pleiotropic Role of Vitamin K in Multimorbidity of Chronic Obstructive Pulmonary Disease.

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Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair.

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Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease.

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Application of the mineral-binding protein fetuin-A for the detection of calcified lesions.

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The BioHybrid Assay: A Novel Method for Determining Calcification Propensity.

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Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification.

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2022

Dysbiosis in Patients with Chronic Kidney Disease: Let Us Talk About Vitamin K.

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Exclusively breastmilk-fed preterm infants are at high risk of developing subclinical vitamin K deficiency despite intramuscular prophylaxis at birth.

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Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial.

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Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases.

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Integrating Mechanisms in Thrombotic Peripheral Arterial Disease.

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Identification and characterization of post-translational modifications: Clinical implications.

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Ageing - Oxidative stress, PTMs and disease.

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Spatial multi-omic map of human myocardial infarction.

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Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis.

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Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients.

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Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification.

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Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells.

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Reply to Janssen et al. Comment on "Kremer et al. Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies. 2021, , 3069".

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro.

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Lipids and lipoproteins in cardiovascular diseases: a classification.

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Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease.

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Influence of rivaroxaban compared to vitamin K antagonist treatment upon development of cardiovascular calcification in patients with atrial fibrillation and/or pulmonary embolism.

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Nanoencapsulation of Gla-Rich Protein (GRP) as a Novel Approach to Target Inflammation.

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Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling.

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Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure.

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Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease.

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Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.

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Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells.

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Corrigendum: Effects of Vitamin D and K on Interleukin-6 in COVID-19.

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VItamin K In PEritonial DIAlysis (VIKIPEDIA): Rationale and study protocol for a randomized controlled trial.

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Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is the Evidence?

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2021

Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study.

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Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019.

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Vitamin K and cardiovascular complications in chronic kidney disease patients.

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Vitamin K-a neglected player in cardiovascular health: a narrative review.

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The role of Extracellular Vesicles during CNS development.

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Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk.

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Locking and loading the bullet against micro-calcification.

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Super-Resolution Imaging of the A- and B-Type Lamin Networks: A Comparative Study of Different Fluorescence Labeling Procedures.

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Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability.

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Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies.

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Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity.

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Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-Bleeding Critically Ill Patients: A Prospective Observational Study.

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Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta.

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Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.

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Beyond Nutrient Deficiency-Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations.

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A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases.

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Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.

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Combined low vitamin D and K status amplifies mortality risk: a prospective study.

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